Quiz 1 Pharmacology 5334 Study online at https://quizlet.com/_4zoun3 1. PCN drug-drug interactions -aminoglycosides -bacteriostatic antibiotics -probenecid 2. Cephalosporin Generation 1 -cephalexin -cephazolin -cephadoxil 3. Cephalosporin and PCN Cross allergy w/PCN 4. Carbapenems not active against MRSA 5. Vancomycin treats gram positive 6. Vancomycin AE ototoxicity, nephrotoxicity, red man syndrome 7. Vancomycin main danger Hosp/vent. pneumonia in pt w/ Crcl less than 50 as it increases mortality 8. Monobactams treats gram negative aerobic 9. Fosfomycin treats enterococcus and Ecoli 10. Aminoglycosides treat gram negative bacilli 11. Aminoglycosides adverse effects ototoxicity and nephrotoxicity 12. aminoglycosides peak and trough Peak: 30 min after IV or IM Trough: divided- before next dose, daily-1 hr before next dose (value should be low: like zero) 13. Sulfonamides MOA inhibit folic acid synthesis 1 / 11 Quiz 1 Pharmacology 5334 Study online at https://quizlet.com/_4zoun3 14. UTI drugs 1) TMP/SMZ and nitrofurantoin 2) levofloxacin & ciprofloxacin 15. UTI in pregnancy TMP/SMZ, Cipro, Levo, augmentin, cephalexin 16. recurrent UTI prophylaxis TMP 17. Recurrent UTI other tx SMZ 3 x week for 6 months; TMP or nitro at bedtime for 6 mos. 18. Acute Bact Prostatitis Tx Floxacins 19. Tetracycline adverse effects -Yellow/brown discoloration of teeth -hepatotoxicity -photosensitivity -GI -suprainfection/superinfection 20. tetracycline absorption is impaired by -magnesium laxative -antacids -Calcium -iron sup. -milk 21. tetracycline treats -lyme dx -anthrax -helicobacter pylori -mycoplasma 22. Linezolid treats VRE and MRSA 23. Telithromycin BBW muscle weakness w/myasthenia gravis 24. Dalfopristin/Quinupristin BBW reserve only for infection when not responding to vanco. to delay resistance 2 / 11 Quiz 1 Pharmacology 5334 Study online at https://quizlet.com/_4zoun3 25. Chloramphenicol BBW fatal aplastic anemia 26. Retapamulin and mupirocin tx topical treatment for impetigo 27. Mupirocin (topical) MRSA in nostrils 28. TB treatment RIPE (rifampin, isoniazid, pyrazinamide, ethambutol); rifapentine and rifabutin 29. TB treatment is effective when no mycobacteria in sputum and no colonies present in culture 30. TB second line injection drugs Amikacin & Capreomycin 31. MDR-TB resistant to isoniazid and rifampin 32. XDR-TB resistant not only to isoniazid and rifampin but also to any fluoroquinolone and at least one of inject. second line drugs 33. TB promoting resistance Daily observed therapy (DOT), intermittent dosing (2-3 times/week) 34. Tx of latent TB INH (isoniazid) daily for 9 months OR INH + Rifampentin for 3 months 35. TB Evaluation 3 modes: -bacterial eval of sputum -clinical eval. -chest radiographs 36. INH adverse effects peripheral neuropathy (vit. b6, pyridoxine), hepatotoxicity, anemia, optic neuritis 37. 3 / 11 Quiz 1 Pharmacology 5334 Study online at https://quizlet.com/_4zoun3 Rifampin adverse effects -Causes discoloration of bodily fluids -GI -cutaneous rxn -hepatotoxic/hepatitis 38. Rifampin drug interactions -Induces P450; can hasten drug metabolism -Oral contraceptives -Warfarin -Drugs for HIV infection 39. Levofloxacin, Moxifloxacin -second line drugs for TB 40. Levofloxacin, Moxifloxacin adverse effects -GI -Tendon rupture 41. Capreomycin Adverse Effects nephrotoxicity and ototoxicity; BBW: disturbed balance 42. Bedaquiline BBW hepatotoxicity 43. Fluroquinolones: Ciprofloxacin AE -tendon rupture -GI -CNS -increased risk of CDI -BBW: myasthenia gravis ^ muscle weakness 44. Fluroquinolones absortion reduced by -aluminum antacid -magnesium antacid -iron & zinc salts -Sulcralfate -milk & dairy products 45. Metronidazole BBW has been shown to be carcinogenic in mice 46. Fidaxomicin treats diarrhea w/C. diff