NURS 6521 Advanced Pharmacology test 1
Beta lactamase inhibitors
Clavulanic acid, sublactam, taxobactam
Unasyn
Ampicillin and sulbactam
Augmentin
Amoxicillin clavulanic acid
Hapten
Drug +plasma protein severe allergic reaction
Mechanisms resistance to beta lactamase
Inactivation by beta lactamase, mutation trans peptidase target, impaired penetration of drug into
organism, drug effluent pumps
MRSA
Resistant organisms produce PBPs with decreased affinity for binding beta lactam antibiotics
Impaired penetration of drug into organosm
Absence of porins or down regulation of porins or porins smaller
Drug efflux pumps
Nonspecific, spit out whatever bacteria doesn't need, major mechanism MDR
Prevention of resistance steains
Testing, choose right antibiotic, complete course therapy, don't use antibiotic when not indicated
Mutidrug resistant organisms
Organisms that are resistant to 1 or more class of organisms. Drug efflux pumps
Penicillin
Bactericidal
Penicillin adverse effects
GI distress, oral/vaginal candidiasis, rash, anaphylaxis
Cephalosporins
More stable against beta lactamases, increased range activity
1st generation cephalosporin