NURS 8024 Pharmacokinetics/Pharmacodynamics TERMS AND DEFINATIONS STUDY GUIDE.
Lipophobic
✔✔AKA hydrophilic
Unable to cross lipid rich cell membranes
Poorly absorbed
Lipid: aqueous partition coefficient
✔✔Determines how easily the molecule moves between aqueous and
lipid media
Partition coefficient
✔✔Ratio of lipid solubility to aqueous solubility
If higher, substance is more membrane soluble
Factors influencing GI absorption
✔✔Blood flow: intestinal blood flow > stomach blood flow
pH: pH of stomach influences absorption (PPI/H2)
Surface area: intestinal surface microvilli
Contact time with absorptive surface: PSNS causes increased rate of gastric
emptying & less contact time; SNS causes decreased rate of gastric
emptying & more contact time; food affects this